Entrepreneurship has emerged as a key driver of economic growth and innovation in developing nations. With the rise of globalization, digital technologies, and access to capital, many developing countries have witnessed a boom in startup activity. However, structural barriers such as limited access to finance, policy instability, and inadequate infrastructure still hamper growth. This paper examines the dynamics of entrepreneurship development and the structure of startup ecosystems in developing nations. The study focuses on ecosystem enablers, government policies, access to finance, innovation, and the role of education in fostering entrepreneurial activity. It concludes by offering strategic recommendations for building resilient and inclusive startup environments in developing economies.